Selected article for: "cell epitope and immune response"

Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity
  • Document date: 2005_2_21
  • ID: 55gi6gyx_36
    Snippet: The hierarchy of T cell responses specific to the various LCMV epitopes is remarkably similar between mice immune only to LCMV (Fig. 1) , but the TCR usage varies between mice and between epitope-specific T cell responses (16, 24, 25) . Because the NP205 response was frequently stimulated in VV-infected LCMV-immune mice, we analyzed the TCR repertoire of MHC-tetramer-sorted NP205specific T cells and, as expected, found considerable heterogeneity .....
    Document: The hierarchy of T cell responses specific to the various LCMV epitopes is remarkably similar between mice immune only to LCMV (Fig. 1) , but the TCR usage varies between mice and between epitope-specific T cell responses (16, 24, 25) . Because the NP205 response was frequently stimulated in VV-infected LCMV-immune mice, we analyzed the TCR repertoire of MHC-tetramer-sorted NP205specific T cells and, as expected, found considerable heterogeneity between mice. It might be anticipated that challenge with a cross-reactive heterologous virus might amplify only a subset of the T cells specific to a given epitope of a previously encountered virus, resulting in a less diverse T cell response. We have not clarified that in the LCMV plus VV system, where the cross-reactivity is unpredictable, but we have studied this in PV-immune mice challenged with LCMV, which invokes a strong cross-reactive NP205 response. Our analyses have shown greatly diminished receptor diversity of the responding T cells (unpublished data), suggesting that limited receptor TCR diversity may be an indicator of a cross-reactive response.

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