Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity Document date: 2005_2_21
ID: 55gi6gyx_4
Snippet: However, protective immunity and the degree of immunopathology varied between experiments, and our attempts to define the epitope specificity of LCMV-specific T cells reactivated by VV were complicated by poor reproducibility in experiments. We have reported that VV frequently expands LCMV NP205-specific T cells from LCMV-immune mice, but this was not always the case. In some mice, there was expansion of T cells specific to other LCMV epitopes (3.....
Document: However, protective immunity and the degree of immunopathology varied between experiments, and our attempts to define the epitope specificity of LCMV-specific T cells reactivated by VV were complicated by poor reproducibility in experiments. We have reported that VV frequently expands LCMV NP205-specific T cells from LCMV-immune mice, but this was not always the case. In some mice, there was expansion of T cells specific to other LCMV epitopes (3, 4) . This led us to question whether the specificities of cross-reactive T cell responses under conditions of heterologous viral challenge may be unique to the individual.
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