Selected article for: "necrosis factor and TNF Î Î"
Author: Tornai, David; Furi, Istvan; Shen, Zu T.; Sigalov, Alexander B.; Coban, Sahin; Szabo, Gyongyi
Title: Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice
  • Document date: 2018_10_29
    • ID: 35jfg45k_2
    Snippet: Despite some recent evidence that peptidoglycan recognition protein 1 (PGLYRP1) may potentially act as a ligand for TREM-1, (12) the actual TREM-1 ligand(s) and molecular mechanisms of TREM-1 signaling are not well understood, impeding the development of clinically relevant inhibitors of TREM-1. Previously, we used our signaling chain homo-oligomerization (SCHOOL) model of TREM-1 signaling (13, 14) binding transcription factor 1; SYK, spleen tyro.....
    Document: Despite some recent evidence that peptidoglycan recognition protein 1 (PGLYRP1) may potentially act as a ligand for TREM-1, (12) the actual TREM-1 ligand(s) and molecular mechanisms of TREM-1 signaling are not well understood, impeding the development of clinically relevant inhibitors of TREM-1. Previously, we used our signaling chain homo-oligomerization (SCHOOL) model of TREM-1 signaling (13, 14) binding transcription factor 1; SYK, spleen tyrosine kinase; TLR, toll-like receptor; TNF-α, tumor necrosis factor α; TREM-1, triggering receptor expressed on myeloid cells 1; UMMS, University of Massachusetts Medical School.

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