Author: Fathi, Anahita; Dahlke, Christine; Addo, Marylyn M.
Title: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens Document date: 2019_9_5
ID: 4cia91cq_17
Snippet: Until now, a small number of children have been included in clinical trials. Despite the observed aforementioned higher viremia in a total of 40 pediatric individuals by Agnandji and colleagues, the vaccine had a comparable safety and immunogenicity profile to that of adults receiving the same dose. 41 A subsequent phase III trial as well as vaccine usage under expanded access showed an acceptable safety profile in over 500 vaccinated children ag.....
Document: Until now, a small number of children have been included in clinical trials. Despite the observed aforementioned higher viremia in a total of 40 pediatric individuals by Agnandji and colleagues, the vaccine had a comparable safety and immunogenicity profile to that of adults receiving the same dose. 41 A subsequent phase III trial as well as vaccine usage under expanded access showed an acceptable safety profile in over 500 vaccinated children aged 6-17. 33,43 Unpublished and ongoing trials are now also including children aged 1 year and above (Médecins Sans Frontières (MSF) (NCT03161366) and PREVAC trials) and will hopefully provide more data on safety and efficacy of VSV-EBOV in the pediatric population.
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