Author: Menachery, Vineet D.; Schäfer, Alexandra; Burnum-Johnson, Kristin E.; Mitchell, Hugh D.; Eisfeld, Amie J.; Walters, Kevin B.; Nicora, Carrie D.; Purvine, Samuel O.; Casey, Cameron P.; Monroe, Matthew E.; Weitz, Karl K.; Stratton, Kelly G.; Webb-Robertson, Bobbie-Jo M.; Gralinski, Lisa E.; Metz, Thomas O.; Smith, Richard D.; Waters, Katrina M.; Sims, Amy C.; Kawaoka, Yoshihiro; Baric, Ralph S.
Title: MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape Document date: 2018_1_30
ID: 096gtdy5_23
Snippet: While not definitive, mutant virus data suggest that both viral proteins and host processes may modulate antigen presentation following MERS-CoV and H5N1-VN1203 infection. Similar to down-regulation of ISGs (6), truncation of H5N1-VN1203 NS1 resulted in augmentation of MHC class I molecules relative to WT infection; importantly, the reduction was not a simple product of lower viral replication, as a similarly attenuated viral mutant maintained do.....
Document: While not definitive, mutant virus data suggest that both viral proteins and host processes may modulate antigen presentation following MERS-CoV and H5N1-VN1203 infection. Similar to down-regulation of ISGs (6), truncation of H5N1-VN1203 NS1 resulted in augmentation of MHC class I molecules relative to WT infection; importantly, the reduction was not a simple product of lower viral replication, as a similarly attenuated viral mutant maintained down-regulation of MHC class I molecules.
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