Selected article for: "class II molecule and MHC class II molecule"
Author: Lundegaard, Claus; Lund, Ole; Kesmir, Can; Brunak, Søren; Nielsen, Morten
Title: Modeling the adaptive immune system: predictions and simulations
  • Document date: 2007_12_15
    • ID: 5m269nzi_4_2
    Snippet: ain (Ii) in the ER and the MHC-Ii complex accumulates in endosomal compartments. Here, Ii is degraded, while another MHC-like molecule, called HLA-DM in humans, loads the MHC class II molecules with the best available ligands originating from endocytosed antigens. The peptide-MHC class II complexes are subsequently transported to the cell surface for presentation to T helper cells......
    Document: ain (Ii) in the ER and the MHC-Ii complex accumulates in endosomal compartments. Here, Ii is degraded, while another MHC-like molecule, called HLA-DM in humans, loads the MHC class II molecules with the best available ligands originating from endocytosed antigens. The peptide-MHC class II complexes are subsequently transported to the cell surface for presentation to T helper cells.

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