Selected article for: "acid model and lung injury"
Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation
  • Document date: 2020_3_25
    • ID: ebwxryai_4
    Snippet: We hypothesized that senescence could be part of the alveolar cell response to lung injury and mechanical stretch, thus, suggesting a novel pathobiologic mechanism and therapeutic target. To test this hypothesis, we first analyzed a previously validated transcriptomic signature of senescence in published data and, based on these findings, we developed a clinically relevant model of lung injury caused by acid aspiration and VILI to characterize th.....
    Document: We hypothesized that senescence could be part of the alveolar cell response to lung injury and mechanical stretch, thus, suggesting a novel pathobiologic mechanism and therapeutic target. To test this hypothesis, we first analyzed a previously validated transcriptomic signature of senescence in published data and, based on these findings, we developed a clinically relevant model of lung injury caused by acid aspiration and VILI to characterize the mechanisms regulating the senescent response.

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