Selected article for: "core ctl and CTL repertoire"
Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition
  • Document date: 1999_7_19
    • ID: 1vabzhs5_17
    Snippet: The same strategy was used to analyze the HCV core 178-specific CTL repertoire in patients with chronic HCV infection without markers for AIH. The percentage of patients having cross-reactive CTLs is comparable to that of healthy donors (Table II) , suggesting that the peripheral pool of naive CTLs specific for HCV core 178 is comparable to the one of uninfected individuals and that the precursor frequency of cross-reactive CTLs is similar. This .....
    Document: The same strategy was used to analyze the HCV core 178-specific CTL repertoire in patients with chronic HCV infection without markers for AIH. The percentage of patients having cross-reactive CTLs is comparable to that of healthy donors (Table II) , suggesting that the peripheral pool of naive CTLs specific for HCV core 178 is comparable to the one of uninfected individuals and that the precursor frequency of cross-reactive CTLs is similar. This is not astonishing, as chronic HCV infection is associated with a low number of CTLs in the peripheral blood (29, 30) .

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