Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h Document date: 2001_7_2
ID: 6n3dmle6_21
Snippet: NK1.1 ϩ CD3 Ϫ Lymphocytes Were Analyzed for IFN-⥠Production in Different Ly49 Subsets. Fig. 4 shows that, whereas no spontaneous IFN-⥠production was made by uninfected splenocytes, PECs, or liver leukocytes, substantial levels were made in all compartments 2 d after MCMV infection. Substantially higher proportions of NK cells made IFN-⥠in the liver and PECs, in comparison to the spleen, perhaps because the liver is a site for substanti.....
Document: NK1.1 Ï© CD3 Ϫ Lymphocytes Were Analyzed for IFN-⥠Production in Different Ly49 Subsets. Fig. 4 shows that, whereas no spontaneous IFN-⥠production was made by uninfected splenocytes, PECs, or liver leukocytes, substantial levels were made in all compartments 2 d after MCMV infection. Substantially higher proportions of NK cells made IFN-⥠in the liver and PECs, in comparison to the spleen, perhaps because the liver is a site for substantial MCMV replication and the peritoneal cavity was the initial site of inoculation, and these sites may be enriched for IFN-â¥-promoting factors, such as IL-12 (34) . In 17 experiments the average percent of NK1.1 Ï© CD3 Ϫ splenocytes spontaneously producing IFN-⥠after MCMV infection was 34 Ï® 16%; in 16 experiments the average in the PECs was 35 Ï® 13%; in six experiments with liver leukocytes the average number was 42 Ï® 14%.
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