Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_51
Snippet: To address the role of p21 in acute lung damage and senescence, Cdkn1a -/mice and their wildtype counterparts were subjected to acid instillation followed by mechanical ventilation. In the absence of p21, the mice had worse lung injury ( Figure 5A ) and higher counts of apoptotic cells compared to their wildtype counterparts ( Figure 5B ). Mutant animals exhibited a decreased number of SAHF after acid instillation and mechanical ventilation ( Fig.....
Document: To address the role of p21 in acute lung damage and senescence, Cdkn1a -/mice and their wildtype counterparts were subjected to acid instillation followed by mechanical ventilation. In the absence of p21, the mice had worse lung injury ( Figure 5A ) and higher counts of apoptotic cells compared to their wildtype counterparts ( Figure 5B ). Mutant animals exhibited a decreased number of SAHF after acid instillation and mechanical ventilation ( Figure 5C ), pointing to the role of p21 in the senescence-like response to mechanical stretch. Additionally, we observed no differences in Tp53 expression ( Figure 5D ), but a decrease in the senescence-related gene Plk3 ( Figure 5E ). There were no differences in gH2AX,
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