Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_55
Snippet: We have previously shown that HIV-protease inhibitors modify the nuclear response to mechanical stretch and protect against VILI (8) , an effect that could be due to the inhibition of the Lamin-A protease ZMPSTE24 (19). In our double-hit model, treatment with lopinavir/ritonavir impaired the structure of the nuclear lamina, decreasing the abundance of Lamin-A ( Figure 6A ), and decreased lung injury ( Figure 6B ) and apoptotic cell count ( Figure.....
Document: We have previously shown that HIV-protease inhibitors modify the nuclear response to mechanical stretch and protect against VILI (8) , an effect that could be due to the inhibition of the Lamin-A protease ZMPSTE24 (19). In our double-hit model, treatment with lopinavir/ritonavir impaired the structure of the nuclear lamina, decreasing the abundance of Lamin-A ( Figure 6A ), and decreased lung injury ( Figure 6B ) and apoptotic cell count ( Figure 6C ). This interference with the nuclear lamina was related to lower counts of SAHF ( Figure 6D ). Although abundance of gH2Ax was not modified by this treatment (Figure 6E ), there was a marked decrease in HP1a ( Figure 6F ). Panel 6G shows representative blots of these measurements.
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