Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial Document date: 2019_5_18
ID: 19ueli6e_19
Snippet: In this exploratory study, the primary outcome was the feasibility of adding rifampicin to b-lactam antibiotics in the treatment of community-acquired pneumococcal pneumonia and the difference in LTA release between patients treated in the intervention group versus the ones in the control group. Secondary outcome variables were LTA-mediated inflammatory response, clinical response, MLPA results and inflammatory biomarkers. Laboratory procedures t.....
Document: In this exploratory study, the primary outcome was the feasibility of adding rifampicin to b-lactam antibiotics in the treatment of community-acquired pneumococcal pneumonia and the difference in LTA release between patients treated in the intervention group versus the ones in the control group. Secondary outcome variables were LTA-mediated inflammatory response, clinical response, MLPA results and inflammatory biomarkers. Laboratory procedures to determine LTA response and LTA-mediated inflammatory response are described in the Supplementary data available at JAC Online.
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