Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_68
Snippet: Local activation of senescence and its paracrine/systemic "spread" could contribute to the pathogenesis of these sequels. As previously discussed, senescence may have a major role in abnormal lung repair. Moreover, the decompartmentalization of the senescent response and spread of the SASP may explain the distant effects. The confirmation of this framework could lead to the use of senolytics (37) in critically ill patients. However, due to the pr.....
Document: Local activation of senescence and its paracrine/systemic "spread" could contribute to the pathogenesis of these sequels. As previously discussed, senescence may have a major role in abnormal lung repair. Moreover, the decompartmentalization of the senescent response and spread of the SASP may explain the distant effects. The confirmation of this framework could lead to the use of senolytics (37) in critically ill patients. However, due to the protective nature of senescence in the early phase, these treatments could be time-coordinated and modulated to optimize their effectiveness.
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