Author: Takamura, Shiki
Title: Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8(+) T Cells Document date: 2017_7_1
ID: 2klytw6c_13
Snippet: It has also been reported that CXCR6 + memory CD8 + T cells accumulate in the lung following intranasal, but not intradermal delivery of antigen (72, 73) . In fact, the expression of CXCL16 is strongly enhanced in response to inflammatory stimuli, thereby accelerating the active re-cruitment of effector T cells into inflamed tissues (2, 38, 85) . Interestingly, this chemokine is constitutively expressed in the lung (18, 127) . These observations .....
Document: It has also been reported that CXCR6 + memory CD8 + T cells accumulate in the lung following intranasal, but not intradermal delivery of antigen (72, 73) . In fact, the expression of CXCL16 is strongly enhanced in response to inflammatory stimuli, thereby accelerating the active re-cruitment of effector T cells into inflamed tissues (2, 38, 85) . Interestingly, this chemokine is constitutively expressed in the lung (18, 127) . These observations strongly suggested that CXCR6 contributes to both active and basal recruitment of CD8 + T cells to the lung.
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