Selected article for: "cancer cell and regulatory rna"
Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load
  • Document date: 2015_10_23
    • ID: 259cspey_12
    Snippet: Inhibition of RT activity in cancer cell lines, either by LINE-1-specific RNA interference or by RT inhibitory drugs, was found to reduce proliferation and promote differentiation and to antagonize tumor growth in animal models. Using CsCl density gradients, Alu-and LINE-1-containing DNA:RNA hybrid structures were identified in cancer yet not in normal cell lines [8] . In cancer cells the highly abundant RT activity intercepts various RNA classes.....
    Document: Inhibition of RT activity in cancer cell lines, either by LINE-1-specific RNA interference or by RT inhibitory drugs, was found to reduce proliferation and promote differentiation and to antagonize tumor growth in animal models. Using CsCl density gradients, Alu-and LINE-1-containing DNA:RNA hybrid structures were identified in cancer yet not in normal cell lines [8] . In cancer cells the highly abundant RT activity intercepts various RNA classes and reverse transcribes them generating RNA:DNA hybrids. This may impair the formation of double-stranded RNAs required in the production of small regulatory RNAs (miRNA in particular), with a direct impact on gene expression. RT inhibition restores the 'normal' small RNA profile and the regulatory networks that depend on them. Thus, the retrotransposonencoded RT drives a previously unrecognized mechanism crucial to the transformed state in tumor cells.

    Search related documents:
    Co phrase search for related documents
    • proliferation reduce and tumor growth: 1, 2
    • regulatory network and RNA interference: 1
    • regulatory network and tumor cell: 1, 2, 3
    • regulatory network and tumor growth: 1, 2, 3
    • regulatory rna and RNA class: 1, 2, 3
    • regulatory rna and RNA interference: 1, 2, 3, 4
    • regulatory rna and small regulatory rna: 1, 2, 3, 4, 5, 6
    • regulatory rna and tumor cell: 1, 2
    • regulatory rna and tumor growth: 1, 2
    • RNA class and small RNA profile: 1
    • RNA interference and RT activity: 1
    • RNA interference and small RNA profile: 1
    • RNA interference and tumor cell: 1, 2, 3
    • RNA interference and tumor growth: 1, 2, 3
    • RNA profile and small RNA profile: 1, 2, 3
    • RNA profile and tumor cell: 1
    • RT activity and RT inhibition: 1, 2, 3, 4
    • RT activity inhibition and RT inhibition: 1, 2, 3
    • RT inhibition and tumor growth: 1