Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_44
Snippet: The role of type I-IFNs in increasing host susceptibility could be explained by modulation of components of the im-mune response involved in controlling the growth of infective agents, such as induction of T cell apoptosis, resulting in greater IL-10 secretion by phagocytic cells, in turn dampening the innate immune response. A mechanism by which viruses survive inside cells is by inactivating the cellular antiviral machinery, or inactivating the.....
Document: The role of type I-IFNs in increasing host susceptibility could be explained by modulation of components of the im-mune response involved in controlling the growth of infective agents, such as induction of T cell apoptosis, resulting in greater IL-10 secretion by phagocytic cells, in turn dampening the innate immune response. A mechanism by which viruses survive inside cells is by inactivating the cellular antiviral machinery, or inactivating the RNA interference response, acting on the dsRNA-activated protein kinase (PKR). Infection thus can escape from the immune response by deregulation of the interferon signaling and the processes forming small RNAs acting in RNA silencing pathways.
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