Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_50
Snippet: Vpr belongs to the RAD23-like family of proteins, similarly to Vpx [66] . Vpr is a chaperone that guides target proteins to bind to VprVP/DCAF1, a receptor of the CULLIN E3 ubiquitin ligase (Cul4-DDB1, Cul5) [67] [68] [69] . Vpx is a small virion-associated adaptor protein encoded by viruses of the HIV-2/SIVsm lineage of primate lentiviruses, a Vpr paralogue, that enables these viruses to infect monocytederived cells......
Document: Vpr belongs to the RAD23-like family of proteins, similarly to Vpx [66] . Vpr is a chaperone that guides target proteins to bind to VprVP/DCAF1, a receptor of the CULLIN E3 ubiquitin ligase (Cul4-DDB1, Cul5) [67] [68] [69] . Vpx is a small virion-associated adaptor protein encoded by viruses of the HIV-2/SIVsm lineage of primate lentiviruses, a Vpr paralogue, that enables these viruses to infect monocytederived cells.
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