Clinical vaccine development

Han, Seunghoon

In the second half of the 20th century, defined by Hilleman [1] as the modern era, scientific improvements related to the screening and manufacturing of vaccine products enabled the development of new types of vaccines. Plotkin and Plotkin [11] regarded the same period as the 'golden age' of vaccine development. This age began with the development of three classical attenuated-virus vaccines against measles, mumps, and rubella (MMR) in the 1960s [12] followed by the varicella zoster virus vaccine and inactivated Japanese encephalitis virus vaccine in the 1970s. All of these vaccines involved cell culture techniques under controlled conditions for a certain purpose (i.e., attenuation) in their manufacturing processes. Inactivated whole hepatitis A virus and cell culture-derived rabies viruses were also developed as vaccine products using similar methodology.