Author: Avirutnan, Panisadee; Hauhart, Richard E.; Marovich, Mary A.; Garred, Peter; Atkinson, John P.; Diamond, Michael S.
Title: Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin Document date: 2011_12_13
ID: 1x3n5job_10
Snippet: MBL exists as an oligomer of homotrimers (14) . Binding of higher-order oligomeric MBL to viruses could cause steric interference between the structural proteins on the virion surface and their cognate ligands, and thus, restrict infection of target cells. To test this, we pretreated insect cell-derived DENV-2 with purified MBL, which forms oligomers similar to native human MBL (27) , before addition to a monolayer of BHK21-15 cells. Binding of p.....
Document: MBL exists as an oligomer of homotrimers (14) . Binding of higher-order oligomeric MBL to viruses could cause steric interference between the structural proteins on the virion surface and their cognate ligands, and thus, restrict infection of target cells. To test this, we pretreated insect cell-derived DENV-2 with purified MBL, which forms oligomers similar to native human MBL (27) , before addition to a monolayer of BHK21-15 cells. Binding of physiological concentrations of MBL to insect cell-derived
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