C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi’s Sarcoma Associated Herpesvirus (KSHV)

William Rodriguez; Aman Srivastav; Mandy Muller

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. Intriguingly, the viral endonucleases tested in this study come from both related and 276 unrelated viruses, do not share the same targeting elements on their target mRNA, and are not 277 known to be recruited to mRNA through similar pathways. It is thus notable that within the group 278 of common escapees was one with a conserved anti-viral role. This underscores the utility of 279 comparative approaches towards revealing broad regulators of viral infection. 280 281 Finally, none of the 3 known SREs (in IL-6, GADD45B, and now in C19ORF66) share 282 significant sequence similarity, although they do all share similar predicted secondary 283 structures. Thus, as predicted before, these RNA elements may function as scaffolds for 284 recruiting a protective protein complex. Therefore, by manipulating the sequence of these RNA 285 All rights reserved. No reuse allowed without permission.