Author: Carvalho, Miguel F.; Gill, Davinder
Title: Rotavirus vaccine efficacy: current status and areas for improvement Document date: 2018_9_19
ID: 14a5861f_8
Snippet: In brief, there are currently two live-attenuated Rotavirus vaccines with global distribution, both of which show higher efficacy in developed nations. China, India and Vietnam also have vaccines licensed locally, and several more are being evaluated in clinical trials worldwide, including nonreplicating vaccines. Further research in thermostable formulations will address the needs of developing nations which often lack the required cold chain ca.....
Document: In brief, there are currently two live-attenuated Rotavirus vaccines with global distribution, both of which show higher efficacy in developed nations. China, India and Vietnam also have vaccines licensed locally, and several more are being evaluated in clinical trials worldwide, including nonreplicating vaccines. Further research in thermostable formulations will address the needs of developing nations which often lack the required cold chain capacity for storage and distribution of vaccines. In the Americas, vaccine efficacy appears to decrease during Rotavirus season. If these observations translate into the rest of the world, adjustments to dosing could potentially improve outcomes of immunization. Live attenuated vaccines are not without risk, as illustrated by RotaShield and mitigation of adverse events through improved dosing regimens and safer strains are therefore important considerations (see below).
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