Author: Vergara-Alert, Júlia; Vidal, Enric; Bensaid, Albert; Segalés, Joaquim
Title: Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus Document date: 2017_3_3
ID: 28vx9w58_19
Snippet: The rhesus macaque was used as the first animal model developed for MERS-CoV infection, showing mild to moderate respiratory disease from day 1 to 4 PI after intratracheal inoculation [21] . Gross lesions were present only in the lung, consisting in congestion and presence of nodules, and the main observed microscopical lesion was interstitial pneumonia. Although MERS-CoV RNA was detected in nasal swabs, bronchoalveolar lavage samples, oropharyng.....
Document: The rhesus macaque was used as the first animal model developed for MERS-CoV infection, showing mild to moderate respiratory disease from day 1 to 4 PI after intratracheal inoculation [21] . Gross lesions were present only in the lung, consisting in congestion and presence of nodules, and the main observed microscopical lesion was interstitial pneumonia. Although MERS-CoV RNA was detected in nasal swabs, bronchoalveolar lavage samples, oropharyngeal swabs, and also in some upper and lower respiratory tract tissue samples, infectious virus was only isolated from the lungs. MERS-CoV replication occurred in type I and II pneumocytes, and viral antigen co-localized with sites of pneumonia [21] . Macaques represent a useful model to study mild MERS-CoV infection because they develop a transient respiratory disease similar to humans.
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