Author: Sousa, Carole; Golebiewska, Anna; Poovathingal, Suresh K; Kaoma, Tony; Pires-Afonso, Yolanda; Martina, Silvia; Coowar, Djalil; Azuaje, Francisco; Skupin, Alexander; Balling, Rudi; Biber, Knut; Niclou, Simone P; Michelucci, Alessandro
Title: Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures Document date: 2018_9_11
ID: 0662rivp_38
Snippet: We thank the reviewer for this suggestion. We added gene expression results regarding inflammatory genes upon LPS treatment in vivo and in vitro (adult and neonatal microglia), accordingly. Specifically, we added Il-1β gene expression analysis obtained from in vivo LPSinjected mice compared to saline control (we added these results in Fig. 2A) . For adult and neonatal cultivated microglia in vitro, we maintained Tmem119 and Gpr34 as representati.....
Document: We thank the reviewer for this suggestion. We added gene expression results regarding inflammatory genes upon LPS treatment in vivo and in vitro (adult and neonatal microglia), accordingly. Specifically, we added Il-1β gene expression analysis obtained from in vivo LPSinjected mice compared to saline control (we added these results in Fig. 2A) . For adult and neonatal cultivated microglia in vitro, we maintained Tmem119 and Gpr34 as representative homeostatic genes and we added Il-1β and Tnf as inflammatory genes (these results are shown in Fig. 2E) .
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