Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Document date: 2015_12_31
ID: 0b08jyjs_20
Snippet: One of the tRF-1 series (namely tRF-1001), derived from pre-tRNA Ser , is highly expressed in several cancer cell lines relative to non-proliferating normal tissues, and is required for proliferation of prostate cancer cells [3] . The levels of tRF-1001 in cancer cells are directly related to the degree of cellular proliferation. Knocking down this tRF causes a dramatic loss of cell viability and inhibition of cell proliferation with specific acc.....
Document: One of the tRF-1 series (namely tRF-1001), derived from pre-tRNA Ser , is highly expressed in several cancer cell lines relative to non-proliferating normal tissues, and is required for proliferation of prostate cancer cells [3] . The levels of tRF-1001 in cancer cells are directly related to the degree of cellular proliferation. Knocking down this tRF causes a dramatic loss of cell viability and inhibition of cell proliferation with specific accumulation of cells in G2 phase and inhibition of DNA synthesis [3] . In addition, analysis of the small RNA transcriptome in prostate cancer revealed enrichment of tRFs in both non-metastatic and metastatic lymph node prostate cancer samples [3] . The molecular mechanism by which tRF-1001 affects cell physiology is not known. There may be a differential processing of tRNA in prostate cancer because tRFs in non-metastatic samples were 18 nucleotides long whereas tRFs in metastatic tissues were 27 nucleotides long [49] .
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