Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Document date: 2015_12_31
ID: 0b08jyjs_21
Snippet: The important role of tRFs in controlling cancer is also supported by the observation showing enhanced ANG expression in almost all types of cancer [50] [51] [52] . Recently, it has been shown that ANG produced tRFs that re-program Y Fu, et al. tRNA-Derived RNA Fragments translation and promote the assembly of stress granules. As these events help cells survive under adverse conditions, it is possible that ANG-induced tRFs may contribute to ANG-m.....
Document: The important role of tRFs in controlling cancer is also supported by the observation showing enhanced ANG expression in almost all types of cancer [50] [51] [52] . Recently, it has been shown that ANG produced tRFs that re-program Y Fu, et al. tRNA-Derived RNA Fragments translation and promote the assembly of stress granules. As these events help cells survive under adverse conditions, it is possible that ANG-induced tRFs may contribute to ANG-mediated cancer cell proliferation [48] . tRFs have also been reported to help cancer cells to prevent apoptosome formation by binding to cytochrome c [53] .
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