Streptococcus suis infection: An emerging/reemerging challenge of bacterial infectious diseases?

Feng, Youjun; Zhang, Huimin; Wu, Zuowei; Wang, Shihua; Cao, Min; Hu, Dan; Wang, Changjun

undergo GI-type T4SS-mediated horizontal transfer in epidemic SS2 species. 28 The systematic elucidation of the of S. suis pathogenesis in the Omics Era was illustrated by functional definition of a collection of other new genes or putative orthologs (such as Zur, a zinc uptake regulator, 29 CovR, an orphan response regulator, 30 and Rgg-like transcription factor 31 ) following the release of the genome sequence of SS2 (e.g., 05ZYH33). 23 Although we have gained a partial glimpse of the molecular mechanism underlying the high pathogenicity of SS2 itself, we are still lacking further insights into the interface between the SS2 pathogen and the host it infects. 3, 8 In this review, we aim to describe an updated but partial picture of SS2 as an emerging infectious agent, which centers on five aspects: global epidemiology/distribution, clinical diagnostics/ typing, pathogenesis, protective antigen/candidate vaccine, and zoonotic potential.