Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats Document date: 2018_10_8
ID: 7ea7ur3b_25
Snippet: To examine the effect of alprostadil on OA-induced ARDS, we first investigated the W/D ratios of lungs in rats. The W/D ratios of lung tissues represent the lung water content, which can be used to indicate lung edema [35] . As shown in Figure 1 , the W/D ratio in the OA model group was significantly increased (P<0.05) compared with that in the control group; however, alprostadil (2.5, 5, 10 μg/kg) treatment decreased the OA-induced W/D ratio co.....
Document: To examine the effect of alprostadil on OA-induced ARDS, we first investigated the W/D ratios of lungs in rats. The W/D ratios of lung tissues represent the lung water content, which can be used to indicate lung edema [35] . As shown in Figure 1 , the W/D ratio in the OA model group was significantly increased (P<0.05) compared with that in the control group; however, alprostadil (2.5, 5, 10 μg/kg) treatment decreased the OA-induced W/D ratio compared with the OA model group. Statistical significance was observed when 10 μg/kg alprostadil was administrated (P<0.05). These results suggest that alprostadil has protective effects on OA-induced lung edema.
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