Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats Document date: 2018_10_8
ID: 7ea7ur3b_6
Snippet: Oleic acid (OA) is a fatty acid derived from animal and plant oils [27] . When administered intravenously, OA induces acute diffuse lung injury, which is similar to the initial phase of ALI and ARDS in humans [28] . Following OA administration, pulmonary vascular endothelial cell injury, local hemorrhage, edema, and inflammation can occur [29, 30] . Thus, use of OA to mimic ARDS in animal models is well established......
Document: Oleic acid (OA) is a fatty acid derived from animal and plant oils [27] . When administered intravenously, OA induces acute diffuse lung injury, which is similar to the initial phase of ALI and ARDS in humans [28] . Following OA administration, pulmonary vascular endothelial cell injury, local hemorrhage, edema, and inflammation can occur [29, 30] . Thus, use of OA to mimic ARDS in animal models is well established.
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