Author: Fathi, Anahita; Dahlke, Christine; Addo, Marylyn M.
Title: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens Document date: 2019_9_5
ID: 4cia91cq_3
Snippet: Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus and a member of the Rhabdoviridae family, consisting of a simple genome organization encoding five structural proteins: the nucleoprotein (N), phosphoprotein (P), matrix (M), glycoprotein (G) and the RNA-dependent RNA polymerase (L). 7 During the last decade, the recombinant VSV (rVSV) platform has been tested for multiple emerging and neglected viral diseases as well as for therap.....
Document: Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus and a member of the Rhabdoviridae family, consisting of a simple genome organization encoding five structural proteins: the nucleoprotein (N), phosphoprotein (P), matrix (M), glycoprotein (G) and the RNA-dependent RNA polymerase (L). 7 During the last decade, the recombinant VSV (rVSV) platform has been tested for multiple emerging and neglected viral diseases as well as for therapeutic cancer vaccines in animal studies. 8 Based on the successful establishment of a method to generate VSV from DNA by Rose et al., effective VSV cloning strategies have been implemented 9 and multiple studies revealed the capacity of VSV to express foreign antigens and thus its potential to be used as vaccine candidates. [10] [11] [12] [13] Benefits of the rVSV platform include (reviewed in 14, 15 ):
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