Author: Fathi, Anahita; Dahlke, Christine; Addo, Marylyn M.
Title: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens Document date: 2019_9_5
ID: 4cia91cq_4
Snippet: (i) fast production of high titers and its propagation in almost all mammalian cells; (ii) lack of reassortment and corresponding potential to undergo genetic shift in vivo; (iii) inability of the vector's viral RNA to integrate into the host genome; (iv) simple genetic modification with the possibility to accommodate one or multiple antigenic inserts; (v) the low seroprevalence in the human population; (vi) mild pathogenicity in humans; (vii) in.....
Document: (i) fast production of high titers and its propagation in almost all mammalian cells; (ii) lack of reassortment and corresponding potential to undergo genetic shift in vivo; (iii) inability of the vector's viral RNA to integrate into the host genome; (iv) simple genetic modification with the possibility to accommodate one or multiple antigenic inserts; (v) the low seroprevalence in the human population; (vi) mild pathogenicity in humans; (vii) induction of humoral and cellular immune responses.
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