Author: Dawson, Wayne K; Lazniewski, Michal; Plewczynski, Dariusz
Title: RNA structure interactions and ribonucleoprotein processes of the influenza A virus Document date: 2017_10_10
ID: 3opbf2cp_11
Snippet: Two additional proteins are also known to be lodged in the nucleocapsid: the nonstructural protein 1 (NS1) and 2 [NS2/nuclear export protein (NEP)], both encoded in Segment 8. NS1 plays a critical role in suppression of the 3 0 -end processing of the host mRNA and blocking the hosts innate immune response stimulated by interferon-a/b [47] [48] [49] . NS2, which is also called the NEP, is a multifunctional protein involved in regulating the accumu.....
Document: Two additional proteins are also known to be lodged in the nucleocapsid: the nonstructural protein 1 (NS1) and 2 [NS2/nuclear export protein (NEP)], both encoded in Segment 8. NS1 plays a critical role in suppression of the 3 0 -end processing of the host mRNA and blocking the hosts innate immune response stimulated by interferon-a/b [47] [48] [49] . NS2, which is also called the NEP, is a multifunctional protein involved in regulating the accumulation of vRNA, antigenomic complementary RNA and viral mRNA synthesized by the vRNA polymerase [9, 50, 51] . The protein is also implicated in the efficient release of budding virions [51, 52] . It seems likely that all of the major expressed proteins are stored in the nucleocapsid to provide additional export, import and viral polymerase functionality, but the exact contents and proportions are unknown.
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