Selected article for: "DENV RNA structure and linear conformation"
Author: Sztuba-Solinska, Joanna; Teramoto, Tadahisa; Rausch, Jason W.; Shapiro, Bruce A.; Padmanabhan, Radhakrishnan; Le Grice, Stuart F. J.
Title: Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome
  • Document date: 2013_3_26
    • ID: 1pbd4maf_48
    Snippet: Our combined probing and mutational analysis also addressed the role of PK1 in the DENV-MINI RNA secondary structure. The 'flipping' mutation introduced into PK1 significantly rearranged the conformation of the 5 0 -and 3 0 -UTRs ( Figure 5 and Supplementary Figures S7, S8 and S9 ). The 5 0 and 3 0 CS became singlestranded, whereas the UAR and DAR, previously required for 5 0 -3 0 communication, became involved in formation of the 5 0 SLB, the 3.....
    Document: Our combined probing and mutational analysis also addressed the role of PK1 in the DENV-MINI RNA secondary structure. The 'flipping' mutation introduced into PK1 significantly rearranged the conformation of the 5 0 -and 3 0 -UTRs ( Figure 5 and Supplementary Figures S7, S8 and S9 ). The 5 0 and 3 0 CS became singlestranded, whereas the UAR and DAR, previously required for 5 0 -3 0 communication, became involved in formation of the 5 0 SLB, the 3 0 sHP and an extended 3 0 SL motif. The presence of 5 0 SLB was proposed as specific for the linear conformation of DENV RNA (39) , reducing the ability of the 5 0 UAR to hybridize to the 3 0 partner (12). In addition, the sHP was suggested to fold locally in the linear conformation of DENV RNA (39) . Although its function is uncertain, the sequences within the sHP were proposed to regulate the equilibrium between the DENV RNA alternative conformations for organizing multiple functions of the viral genome.

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