Title: The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane Document date: 1993_2_1
ID: 3qi2llmr_32
Snippet: The other carboxy-terminally truncated LBR construct (truncated at residue 206) contained only the nucleoplasmic domain of LBR, lacked all of the eight transmembrane domains and therefore was referred to as p58ATM1-8 (see cartoon in Fig. 4 B) . Interestingly this protein localized exclusively to the nucleus, excluding nucleoli, with no detectable enrichment at the nuclear rim (Fig. 4 B) . The exclusive nuclear localization suggests that this prot.....
Document: The other carboxy-terminally truncated LBR construct (truncated at residue 206) contained only the nucleoplasmic domain of LBR, lacked all of the eight transmembrane domains and therefore was referred to as p58ATM1-8 (see cartoon in Fig. 4 B) . Interestingly this protein localized exclusively to the nucleus, excluding nucleoli, with no detectable enrichment at the nuclear rim (Fig. 4 B) . The exclusive nuclear localization suggests that this protein enters the nucleus and perhaps by virtue of an affinity for a chromatin component is retained there (see Discussion).
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