Selected article for: "antibiotic treatment and rifampicin treatment"
Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial
  • Document date: 2019_5_18
    • ID: 19ueli6e_63
    Snippet: In conclusion, the PRISTINE exploratory study demonstrated the feasibility of adding rifampicin to b-lactam antibiotics in the Non-lytic antibiotic treatment effect on inflammation in CAP JAC treatment of community-acquired pneumococcal pneumonia; however, despite solid in vitro and experimental animal research evidence, it failed to demonstrate a difference in LTA and subsequent inflammatory response. Further studies in selected groups of patien.....
    Document: In conclusion, the PRISTINE exploratory study demonstrated the feasibility of adding rifampicin to b-lactam antibiotics in the Non-lytic antibiotic treatment effect on inflammation in CAP JAC treatment of community-acquired pneumococcal pneumonia; however, despite solid in vitro and experimental animal research evidence, it failed to demonstrate a difference in LTA and subsequent inflammatory response. Further studies in selected groups of patients, such as those with pneumococcal meningitis, will be necessary to confirm the hypothesis that non-lytic antibiotic treatment attenuates inflammatory response and improves clinical outcome. Groeneveld et al.

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