Selected article for: "age group and respiratory disease"
Author: Lambert, Stephen Bernard; Ware, Robert S; Cook, Anne L; Maguire, Frances A; Whiley, David M; Bialasiewicz, Seweryn; Mackay, Ian M; Wang, David; Sloots, Theo P; Nissen, Michael D; Grimwood, Keith
Title: Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
  • Document date: 2012_10_31
    • ID: 06e9lkwl_25
    Snippet: As respiratory syncytial virus (RSV) is the most widely recognised respiratory agent associated with severe disease in this age group, we chose it to use for sample size calculations. To calculate the proportion of pathogens detected that are RSV to within ±2.5%, we assumed the current proportion Lambert 13 ) and that 90% of subjects will remain enrolled at study completion (previous large cohort studies conducted by the investigators had retent.....
    Document: As respiratory syncytial virus (RSV) is the most widely recognised respiratory agent associated with severe disease in this age group, we chose it to use for sample size calculations. To calculate the proportion of pathogens detected that are RSV to within ±2.5%, we assumed the current proportion Lambert 13 ) and that 90% of subjects will remain enrolled at study completion (previous large cohort studies conducted by the investigators had retention rates of 97-98%). 13 63 Consequently, with α=0.05 and power of 80%, we were required to enrol 138 infants. Similarly, if each subject returns 80% of their weekly nasal swabs, 13 we will be able to estimate the proportion of all swabs positive for RSV to within ±0.5%.

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