Author: Rao, Xiaoquan; Zhao, Shi; Braunstein, Zachary; Mao, Hong; Razavi, Michael; Duan, Lihua; Wei, Yingying; Toomey, Amelia C.; Rajagopalan, Sanjay; Zhong, Jixin
Title: Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways Document date: 2019_2_7
ID: 1n7xjjd5_30
Snippet: Activation of TLR4 may occur through binding of atherogenic lipids on receptors such as CD36, providing the proximal signaling event required for proinflammatory mediators, chemokines, inflammasome activation and ER stress [18] [19] [20] . We therefore initially examined the dependence of TLR4 as a proximal trigger for the induction of DPP4. We induced TLR4 activation with lipopolysaccharide (LPS) stimulation and examined expression of DPP4. LPS .....
Document: Activation of TLR4 may occur through binding of atherogenic lipids on receptors such as CD36, providing the proximal signaling event required for proinflammatory mediators, chemokines, inflammasome activation and ER stress [18] [19] [20] . We therefore initially examined the dependence of TLR4 as a proximal trigger for the induction of DPP4. We induced TLR4 activation with lipopolysaccharide (LPS) stimulation and examined expression of DPP4. LPS enhanced the expression of DPP4 on human monocytes, while siRNA-mediated knockdown of TLR4 substantially abrogated LPS-induced DPP4 up-regulation (Figs. 3a & 3b) .
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