Author: Li, Yuetao; Zhao, Yongkun; Wang, Cuiling; Zheng, Xuexing; Wang, Hualei; Gai, Weiwei; Jin, Hongli; Yan, Feihu; Qiu, Boning; Gao, Yuwei; Li, Nan; Yang, Songtao; Xia, Xianzhu
Title: Packaging of Rift Valley fever virus pseudoviruses and establishment of a neutralization assay method Document date: 2018_3_23
ID: 4nphwznx_34
Snippet: RVFV is a high-risk pathogen that can be transmitted through insect bites or direct contact. Therefore, its physical manipulation poses enormous safety concerns for veterinary workers and laboratory personnel. This issue severely limits studies on the genomic structure and pathogenic mechanism of RVFV. Under normal circumstances, vaccines can induce high neutralizing antibody titers in humans, so neutralizing antibody titers are an important indi.....
Document: RVFV is a high-risk pathogen that can be transmitted through insect bites or direct contact. Therefore, its physical manipulation poses enormous safety concerns for veterinary workers and laboratory personnel. This issue severely limits studies on the genomic structure and pathogenic mechanism of RVFV. Under normal circumstances, vaccines can induce high neutralizing antibody titers in humans, so neutralizing antibody titers are an important indicator of the immune effect of vaccines. However, traditional RVFV virus neutralization assays involve tedious work, including culture of the virus, which can be performed only in biological safety level 3 laboratories, thus limiting the application of neutralization assays in the monitoring, detection, and diagnosis of RVFV infection and in the evaluation of the effects of vaccines on RVFV infection. Therefore, safety issues associated with RVFV is an important problem that has drawn considerable attention, and such issues need to be addressed in studies targeting high-risk viruses such as RVFV [1, 2] .
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