PATRIC: The VBI PathoSystems Resource Integration Center

Snyder, E. E.; Kampanya, N.; Lu, J.; Nordberg, E. K.; Karur, H. R.; Shukla, M.; Soneja, J.; Tian, Y.; Xue, T.; Yoo, H.; Zhang, F.; Dharmanolla, C.; Dongre, N. V.; Gillespie, J. J.; Hamelius, J.; Hance, M.; Huntington, K. I.; Jukneliene, D.; Koziski, J.; Mackasmiel, L.; Mane, S. P.; Nguyen, V.; Purkayastha, A.; Shallom, J.; Yu, G.; Guo, Y.; Gabbard, J.; Hix, D.; Azad, A. F.; Baker, S. C.; Boyle, S. M.; Khudyakov, Y.; Meng, X. J.; Rupprecht, C.; Vinje, J.; Crasta, O. R.; Czar, M. J.; Dickerman, A.; Eckart, J. D.; Kenyon, R.; Will, R.; Setubal, J. C.; Sobral, B. W. S.

After curatorial review, finalized protein-coding (CDS) features are translated and subjected to another pipeline executing InterProScan and structure prediction methods such as MEMSAT 2 (29) . Currently, each protein is associated with GO terms (30), TIGRroles, Enzyme Commission numbers (31) based on Pfam (32) and TIGRfam alignments (for a description of TIGRfam and TIGRroles, see: http://www. tigr.org/TIGRFAMs/). The protocol for automated proteome annotation is also available online. Manually curated protein sequences will be available in early 2007.