Selected article for: "epidemic course and public health"
Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study
  • Document date: 2016_11_10
    • ID: 02pjdufw_5
    Snippet: To strengthen the evidence base for the public health benefit of dose fractionation of YF vaccines, we use simple mathematical models to assess the potential reduction in infection attack rate (IAR, defined as the proportion of population infected over the course of a sustained epidemic) conferred by five-fold dose fractionation under different epidemic scenarios and reductions in vaccine efficacy. We find that all dose-sparing strategies conside.....
    Document: To strengthen the evidence base for the public health benefit of dose fractionation of YF vaccines, we use simple mathematical models to assess the potential reduction in infection attack rate (IAR, defined as the proportion of population infected over the course of a sustained epidemic) conferred by five-fold dose fractionation under different epidemic scenarios and reductions in vaccine efficacy. We find that all dose-sparing strategies considered are likely to provide significant benefit epidemiologically, and that the best policy will be determined by balancing logistical and regulatory considerations against the extent of epidemiologic benefit. In particular, we conclude that the WHO Kinshasa dosesparing vaccination campaign in July-August 2006 would be an effective strategy for reducing infection attack rate, and the results would be robust against a large margin for error in case five-fold fractional-dose efficacy turns out to be lower than expected.

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