Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_11_10
ID: 02pjdufw_51
Snippet: We first provide mathematical details on IAR calculations for the case where the population is not stratified into subgroups. If vaccine action is all-or-nothing, then IAR with fractionation n, denoted by IAR(n), is obtained by solving the equation where R 0 is the basic reproductive number, S 0 and I 0 are the initial proportion of population that are susceptible and infectious. As such, dose fractionation reduces IAR if and only if VE(n) > VE(1.....
Document: We first provide mathematical details on IAR calculations for the case where the population is not stratified into subgroups. If vaccine action is all-or-nothing, then IAR with fractionation n, denoted by IAR(n), is obtained by solving the equation where R 0 is the basic reproductive number, S 0 and I 0 are the initial proportion of population that are susceptible and infectious. As such, dose fractionation reduces IAR if and only if VE(n) > VE(1)/n. If vaccine action is leaky, then IAR(n) is obtained by solving the equation
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