Selected article for: "asthma development and develop asthma"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_23
    Snippet: The human GSDMB gene belongs to the Gasdermin gene family, and it is highly expressed in bronchial epithelial cells and T cells. 43 Transgenic mice expressing human GSDMB develop an asthma phenotype characterized by the spontaneous development of increased AHR and airway remodeling (increased airway smooth muscle mass and peribronchial fibrosis) without development of airway inflammation. 43 In vitro overexpression of human GSDMB in human bronchi.....
    Document: The human GSDMB gene belongs to the Gasdermin gene family, and it is highly expressed in bronchial epithelial cells and T cells. 43 Transgenic mice expressing human GSDMB develop an asthma phenotype characterized by the spontaneous development of increased AHR and airway remodeling (increased airway smooth muscle mass and peribronchial fibrosis) without development of airway inflammation. 43 In vitro overexpression of human GSDMB in human bronchial epithelial cells upregulates several genes associated with airway remodeling (i.e. TGF-β1, 5-LO and MMP-9). 3 At present no published human studies have investigated whether GSDMB genetic variants are associated with features of airway remodeling in asthma.

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