Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma Document date: 2019_6_4
ID: 6j3k3viu_29
Snippet: To date, there has been only 1 study of 419 asthmatics investigating whether TGFB1 genetic polymorphisms are associated with decline in lung function. 50 In this study, among 6 candidate TGFB1 SNPs, 1 TGFB1 SNP rs4803455-A was associated with an accelerated FEV1 decline in asthma (P = 0.003), while 2 other TGFB1 SNPs rs1800469-T and rs1800470-C were associated with protecting against lung function decline (P = 0.06 and P = 0.002, respectively). T.....
Document: To date, there has been only 1 study of 419 asthmatics investigating whether TGFB1 genetic polymorphisms are associated with decline in lung function. 50 In this study, among 6 candidate TGFB1 SNPs, 1 TGFB1 SNP rs4803455-A was associated with an accelerated FEV1 decline in asthma (P = 0.003), while 2 other TGFB1 SNPs rs1800469-T and rs1800470-C were associated with protecting against lung function decline (P = 0.06 and P = 0.002, respectively). Thus, at present there is evidence that some TGFB1 SNPs are associated with an accelerated FEV1 decline, while other TGFB1 SNPs protect against lung function decline. No studies have reported whether TGFB1 SNPs are linked to airway remodeling.
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