Selected article for: "asthma lung function and genetic variant"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_43
    Snippet: CysLTs are important proinflammatory lipid mediators derived from the lipoxygenase pathway of arachidonic acid metabolism. 59 The CysLTs may play an important role in airway remodeling as they increase airway smooth muscle, myofibroblasts, airway fibrosis and mucus. 60 In mouse models of asthma, a CysLTs antagonist (Montelukast) reduced the features of airway remodeling including smooth muscle hyperplasia and mucus plugging. 61 Studies have also .....
    Document: CysLTs are important proinflammatory lipid mediators derived from the lipoxygenase pathway of arachidonic acid metabolism. 59 The CysLTs may play an important role in airway remodeling as they increase airway smooth muscle, myofibroblasts, airway fibrosis and mucus. 60 In mouse models of asthma, a CysLTs antagonist (Montelukast) reduced the features of airway remodeling including smooth muscle hyperplasia and mucus plugging. 61 Studies have also investigated whether SNPs in genes regulating enzymes in the CysLT pathway are associated with lung function. For example, previous studies have investigated the effect on lung function of SNPs in 5-lipoxygenease (encoded by ALOX5) as well as SNPs in 5-lipoxygenase activating protein also known as FLAP (encoded by ALOX5AP). 62 The ALOX5 genetic variant rs5943948 has been associated with lower FEV1% levels (84% vs. 91%, P = 0.017) and higher urinary LTE4 levels (P = 0.0134) in 270 children with poorly controlled asthma. 63 The ALOX5AP SNP rs9506352 has been associated with FEV1% (P = 0.032) in a healthy polulation. 64 At present, there have been no published studies investigating whether ALOX5 or ALOX5AP SNPs are associated with decline in lung function or the development of airway remodeling in asthma.

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