Author: George, Melissa R
Title: Hemophagocytic lymphohistiocytosis: review of etiologies and management Document date: 2014_6_12
ID: 3frxd1c1_32
Snippet: Prior to the use of modern treatment regimens, survival with HLH was close to 0%. 202 Broadly, treatment of HLH involves immune-suppressive and modulatory agents, biological response modifiers, treatment of the inciting illness if secondary, and subsequent stem-cell transplantation. Therapy is aimed at suppressing the hyperinflammatory state and immune dysregulation that leads to life-threatening organ damage and susceptibility to deadly infectio.....
Document: Prior to the use of modern treatment regimens, survival with HLH was close to 0%. 202 Broadly, treatment of HLH involves immune-suppressive and modulatory agents, biological response modifiers, treatment of the inciting illness if secondary, and subsequent stem-cell transplantation. Therapy is aimed at suppressing the hyperinflammatory state and immune dysregulation that leads to life-threatening organ damage and susceptibility to deadly infections. It is also important to kill infected antigen-presenting cells to remove the stimulus for ongoing immune activation. Treatment of HLH may vary according to cause. Discussion of treatment is subdivided into FHL, infection-related, malignancyassociated, and autoimmune diseases.
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