2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

In a randomized, double-blind, 4-way crossover design, 8 healthy cats were administered placebo (saline PO or SC), metoclopramide (0.5 mg/kg SC q8h), erythromycin (1 mg/kg PO q8h) or exenatide (1.2 μg/ kg SC q12h) for 2 consecutive days followed by a minimum 5-day washout period. Cats were randomized to a treatment group. Sonographic assessment of GE was performed in dorsal recumbency at 0, 15, 30 and 60 minutes following a solid test meal (20% of daily energy requirements), and at 30-minute intervals thereafter for 8 hours. Mean cross-sectional area of transverse images of the relaxed antrum was obtained for each time point, and expressed as a percentage of the maximal antral area. The area under the curve (AUC) was calculated and 25% -90% GE times (GET) determined. The motility index (MI) of antral contractions was plotted against time. A mixed model ANOVA with cat as a random effect and treatment as fixed effect was used to assess the difference in each fractional GET and MI AUC between treatments. Posthoc pairwise comparisons were examined with the Tukey';s test as appropriate.