Selected article for: "array resequencing and genome resequencing"
Author: Pandya, Gagan A.; Holmes, Michael H.; Sunkara, Sirisha; Sparks, Andrew; Bai, Yun; Verratti, Kathleen; Saeed, Kelly; Venepally, Pratap; Jarrahi, Behnam; Fleischmann, Robert D.; Peterson, Scott N.
Title: A bioinformatic filter for improved base-call accuracy and polymorphism detection using the Affymetrix GeneChip® whole-genome resequencing platform
  • Document date: 2007_11_15
    • ID: 16tii0ha_30
    Snippet: Most array-based resequencing studies use purified PCR products rather than whole-genome DNA as described here. We wished to test whether, despite their additional complexity, genomic DNA samples could be reliably resequenced and what specific impediments might be encountered. Hybridization of a whole-genome sample on an Affymetrix Õ resequencing array platform can lead to incorrect base calls due to a number of systematic effects. Most of these.....
    Document: Most array-based resequencing studies use purified PCR products rather than whole-genome DNA as described here. We wished to test whether, despite their additional complexity, genomic DNA samples could be reliably resequenced and what specific impediments might be encountered. Hybridization of a whole-genome sample on an Affymetrix Õ resequencing array platform can lead to incorrect base calls due to a number of systematic effects. Most of these adverse effects were predictable and therefore could be accounted for through application of specific bioinformatic data processing. These effects, and the bioinformatic filters, are described in Materials and Methods section.

    Search related documents:
    Co phrase search for related documents
    • array base and base call: 1, 2, 3
    • array platform and dna sample: 1, 2
    • array platform and genome sample: 1
    • array platform and PCR product: 1, 2
    • base call and dna sample: 1, 2
    • base call and genome dna: 1, 2
    • base call and genome sample: 1
    • dna sample and genome dna: 1, 2, 3, 4, 5, 6
    • dna sample and genome sample: 1, 2, 3, 4, 5, 6, 7
    • dna sample and genomic dna sample: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • dna sample and Methods material: 1
    • genome dna and Methods material: 1