Author: Gao, Mengqi; Lin, Yi; Liu, Xing; Li, Yiming; Zhang, Chuanbao; Wang, Zheng; Wang, Zhiliang; Wang, Yulin; Guo, Zongze
Title: ISG20 promotes local tumor immunity and contributes to poor survival in human glioma Document date: 2018_10_31
ID: 6m4q219k_14
Snippet: To further confirm these initial findings, we next studied the intratumoral immune cell infiltrates from 43 glioma patients with immunostaining and compared their immune cell profiles relative to ISG20 expression ( Figure 5(c,d) ). In line with the bioinformatic findings, the composition of the immune infiltrates differed between the low ISG20 expression group and the high ISG20 expression group, with a more substantial number of macrophages and .....
Document: To further confirm these initial findings, we next studied the intratumoral immune cell infiltrates from 43 glioma patients with immunostaining and compared their immune cell profiles relative to ISG20 expression ( Figure 5(c,d) ). In line with the bioinformatic findings, the composition of the immune infiltrates differed between the low ISG20 expression group and the high ISG20 expression group, with a more substantial number of macrophages and lower number of the T cell subsets (T cells, Tfh cells, memory T cells) in high ISG20 expression tumors. Moreover, microglia and cytotoxic T cells were not associated with the ISG20 protein level.
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