Author: Kruse, Susanne; Zhong, Silin; Bodi, Zsuzsanna; Button, James; Alcocer, Marcos J. C.; Hayes, Christopher J.; Fray, Rupert
Title: A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA Document date: 2011_10_24
ID: 69vuc6l9_12
Snippet: Conversion of an adenosine following the m 7 G cap to Am (cap1) can be followed by further conversion to m 6 Am (Fig. 1a, and 1c) . It is not known if this Am to m 6 Am conversion preferentially targets certain messages, or if the Am:m 6 Am ratio for messages from any one gene is merely a reflection of the general m 6 Am methylase activity of a particular cell type. The enzyme responsible for the formation of m 6 Am has been partially characteris.....
Document: Conversion of an adenosine following the m 7 G cap to Am (cap1) can be followed by further conversion to m 6 Am (Fig. 1a, and 1c) . It is not known if this Am to m 6 Am conversion preferentially targets certain messages, or if the Am:m 6 Am ratio for messages from any one gene is merely a reflection of the general m 6 Am methylase activity of a particular cell type. The enzyme responsible for the formation of m 6 Am has been partially characterised 5 . It appears to be a cytosolic enzyme and is distinct from METTL3/MT-A70, the nuclear enzyme responsible for the formation of m 6 A at internal positions within mRNA 33 .
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