Author: Lee, Kyung-Yil; Rhim, Jung-Woo; Kang, Jin-Han
Title: Kawasaki Disease: Laboratory Findings and an Immunopathogenesis on the Premise of a ""Protein Homeostasis System Document date: 2012_3_1
ID: 7ik3iszp_21_2
Snippet: ch and infect endothelial cells of the coronary artery as main target cells via systemic circulation. Immune cells, including previously primed CD8 T cells and IgA B cells in initial lymphoid tissues, are re-recruited to infected target tissues and contribute to the inflammatory response within the tissues. Differentiated IgA B plasma cells produce antigen-specific antibodies, and CD8 T cells attack infected cells by cytotoxic mechanisms. The pro.....
Document: ch and infect endothelial cells of the coronary artery as main target cells via systemic circulation. Immune cells, including previously primed CD8 T cells and IgA B cells in initial lymphoid tissues, are re-recruited to infected target tissues and contribute to the inflammatory response within the tissues. Differentiated IgA B plasma cells produce antigen-specific antibodies, and CD8 T cells attack infected cells by cytotoxic mechanisms. The products from infected cells and immune cells including MMPs result in destruction of collagen and elastin fibers, and form an aneurysm. The immune response is ultimately successful in controlling the pathogen, particularly if IVIG is given, because IVIG may have antibodies to KD agents and have a role in antibody dependent cellular cytotoxicity to infected cells. 16
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