Author: Theis, Corinna; Reeder, Jens; Giegerich, Robert
Title: KnotInFrame: prediction of -1 ribosomal frameshift events Document date: 2008_9_27
ID: 4ov0j2u3_48
Snippet: We presented KnotInFrame, a new and efficient tool for the automated detection of ribosomal À1 frameshift events. KnotInFrame employs a specialized RNA-folding program at its core to distinguish true À1 PRF events from random ones. The complete pipeline is fast enough to analyze complete genome sequences within a few hours. Our evaluation shows a high sensitivity on annotated À1 PRF events from the RECODE database. KnotInFrame clearly outperfo.....
Document: We presented KnotInFrame, a new and efficient tool for the automated detection of ribosomal À1 frameshift events. KnotInFrame employs a specialized RNA-folding program at its core to distinguish true À1 PRF events from random ones. The complete pipeline is fast enough to analyze complete genome sequences within a few hours. Our evaluation shows a high sensitivity on annotated À1 PRF events from the RECODE database. KnotInFrame clearly outperforms previous approaches in terms of compute resources. With our new method it is now possible to systematically annotate available genome sequences. Positive results of such screens will help to further improve the tool's accuracy.
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